咖啡戒断反应头痛怎么办？专家支招What to do with coffee withdrawal symptoms and headaches? Expert Recruitment

你可能也有这样的经历：平时上班一天一杯咖啡，周末不喝就头疼。这可能和咖啡戒断反应头痛有关。

南京市第二医院神经内科主任医师王蔚在接受媒体采访时介绍，我们脑内有一种叫做“腺苷”的物质，它与“腺苷受体”结合后，会抑制神经活动，让人产生困意和疲惫感。而咖啡因的分子结构与腺苷非常相似，它进入大脑后会“抢”在腺苷前面，与腺苷受体相结合。“咖啡因跟腺苷受体结合后，神经抑制就被解除了，人自然就兴奋起来，困意也就消失了。”王蔚说。

如果咖啡因长期占据受体，大脑就会反射性地增加受体的数量，简单来说，原本50个受体变成了100个，身体对咖啡因产生了耐受。“你需要喝更多的咖啡才能达到原来的提神效果，这就是为什么有些人越喝越多。”

一旦身体适应了这种高水平的受体数量，突然停止摄入咖啡因，咖啡因不再与受体结合，人体自身产生的腺苷就会“蜂拥而上”，与多达100个受体结合，导致神经被过度抑制。“过度抑制的结果就是脑血管扩张，从而引发头痛、乏力、情绪变差等戒断反应。”

那么如何避免或减轻这种戒断性头痛呢？王蔚指出，首先不要突然完全停止喝咖啡。她建议长期饮用者可以每天逐渐减少饮用量，比如从两杯减到一杯半，再减到一杯。其次，不要养成长期大量饮用咖啡的习惯，推荐间断、小量饮用，以保持受体数量的相对平衡。“受体没那么多了，一旦不喝，戒断反应自然就不会那么明显。”

来源：人民日报健康客户端

You may also have had the experience of having a cup of coffee a day at work, but getting a headache on weekends if you don't drink it. This may be related to coffee withdrawal symptoms and headaches.

Wang Wei, chief physician of the Department of Neurology at Nanjing Second Hospital, introduced in an interview with the media that there is a substance called "adenosine" in our brain. When it binds to the "adenosine receptor", it inhibits neural activity, causing drowsiness and fatigue. The molecular structure of caffeine is very similar to that of adenosine. After entering the brain, it "competes" with adenosine and binds to adenosine receptors. After caffeine binds to adenosine receptors, neural inhibition is released, and people naturally become excited, and drowsiness disappears, "said Wang Wei.

If caffeine occupies receptors for a long time, the brain will reflexively increase the number of receptors. Simply put, the original 50 receptors have become 100, and the body has developed tolerance to caffeine. You need to drink more coffee to achieve the original refreshing effect, which is why some people drink more and more

Once the body adapts to this high level of receptor quantity and suddenly stops consuming caffeine, caffeine no longer binds to receptors, and the adenosine produced by the body itself will "swarm up" and bind to up to 100 receptors, leading to excessive inhibition of nerves. The result of excessive inhibition is cerebral vasodilation, which can lead to withdrawal reactions such as headaches, fatigue, and decreased mood

So how to avoid or alleviate this withdrawal headache? Wang Wei pointed out that firstly, do not suddenly stop drinking coffee completely. She suggests that long-term drinkers can gradually reduce their daily consumption, such as from two cups to one and a half cups, and then to one cup. Secondly, do not develop the habit of drinking coffee in large quantities for a long time. It is recommended to drink intermittently and in small quantities to maintain a relative balance in the number of receptors. There aren't so many receptors left, so once you don't drink, the withdrawal symptoms naturally won't be so obvious

Source: People's Daily Health Client